BPC-157

BPC-157 Overview

BPC-157 (Body Protection Compound-157) is a pentadecapeptide consisting of 15 amino acids, originally derived from a naturally occurring protein fragment isolated from gastric tissue. Since its initial characterization in the early 1990s, BPC-157 has been investigated in laboratory and preclinical research models for its potential biological activity related to cellular protection, tissue remodeling, and vascular processes.[1]

History

Interest in BPC-157 began with research into cytoprotective proteins found in gastric juice. Early work focused on structural integrity in gastrointestinal experimental models, where BPC-157 demonstrated protective properties under laboratory conditions.[1,2]

Over the next several decades, research expanded into tendon, ligament, muscle, vascular, neurological, and dermal experimental systems. These in-vitro and animal studies consistently highlighted BPC-157’s potential influence on angiogenesis, fibroblast activity, and extracellular matrix support.[3–6]

BPC-157 Structure

Chemical Name: Pentadecapeptide BPC-157
Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
CAS Number: 137525-51-0
Molecular Formula: C₆₂H₉₈N₁₆O₂₂
Molecular Weight: 1419.556 g/mol
PubChem CID: 108101

Research Focus Areas

BPC-157 has been studied in multiple non-human laboratory settings, including cell culture and animal models. Reported areas of scientific investigation include:

1. Structural + Musculoskeletal Research

Experimental data suggest potential roles in fibroblast behavior, tendon outgrowth, and extracellular matrix formation.[3,4]

2. Vascular & Angiogenic Pathways

Several studies report increased collateral vessel growth and modulation of nitric-oxide signaling in ischemic animal models.[5,6]

3. Gastrointestinal Integrity

Preclinical colitis studies indicate protective effects on stomach and intestinal tissues in rat models.[7]

4. Neurological & Systemic Stress Models

Various investigations explore responses to experimental toxicity, ischemia, and inflammatory injury.[8,9]

5. Microbial & Environmental Applications

Research has extended into veterinary and ecological studies, including honeybee gut health models involving Nosema ceranae infection.[10]

Scientific Summary

Across structural, vascular, gastrointestinal, and systemic research domains, BPC-157 has been repeatedly examined for its potential biological activity under controlled laboratory conditions. While findings vary across models, the overall body of research continues to expand, providing a foundation for further scientific evaluation into peptide-regulated repair mechanisms, angiogenesis, and cellular resilience.[5,6,8]

Important Research Notice

Current published research on BPC-157 has been conducted primarily in in-vitro and animal models. BPC-157 has not been approved by the FDA for human consumption, medical use, therapeutic application, or dietary supplementation. Research findings do not establish safety, efficacy, or clinical outcomes in humans.

References

1. Sikiric P. et al. “A new gastric juice peptide, including BPC-157, characterized and synthesized.” Life Sci., 1993.

2. Pflaum M., Ručman R. “Cytoprotective peptides in gastric tissue.” Eur. J. Pharmacol., 2005.

3. Pavlovic I. et al. “Pentadecapeptide BPC-157 and tendon healing.” J. Appl. Physiol., 2003.

4. Staresinic M. et al. “Effects of BPC-157 on ligament and tendon repair.” J. Orthop. Res., 2003.

5. Hsieh M-J. et al. “Pro-angiogenic potential of BPC-157.” J. Mol. Med., 2017.

6. Seiwerth S. et al. “Angiogenic mechanisms and NO-system modulation by BPC-157.” Curr. Pharm. Des., 2018.

7. Chang C-H. et al. “Protective effects of BPC-157 in colitis models.” World J. Gastroenterol., 2009.

8. Amic F. et al. “BPC-157 and gastrointestinal experimental lesions.” World J. Gastroenterol., 2018.

9. Drmic D. et al. “Celecoxib-induced GI injury and BPC-157 counteraction.” World J. Gastroenterol., 2017.

10. Tlak Gajger I. et al. “BPC-157 in honeybee Nosema ceranae infection models.” J. Vet. Pharmacol. Ther., 2018.

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