Research Use Only: These products are sold for research use only, and are prohibited by law for human or animal consumption.
GLP-1/GIP/Glucagon analog examined in multi-receptor biochemical research models.
For research use only.
Price range: $129.00 through $219.00
Peptides will arrive in a lyophilized (powder) form for maximum stability
Retatrutide is an investigational synthetic peptide studied for its interaction with three metabolic hormone receptors: GLP-1, GIP, and glucagon receptors. Research explores its influence on metabolic signaling, energy regulation, insulin sensitivity, and hormonal communication within controlled laboratory environments and cellular research systems.[1]
Retatrutide represents the latest progression in incretin-based metabolic research. Earlier scientific work centered on GLP-1 receptor agonists, revealing their importance in glucose regulation and appetite signaling. Subsequent research expanded into dual-agonist peptides targeting both GLP-1 and GIP pathways. Building on these findings, Retatrutide was developed in the 2020s as a next-generation investigational compound designed to study coordinated signaling across GLP-1, GIP, and glucagon receptors — offering a broader structural framework for examining integrated metabolic biology.[2]
Sequence: YA1QGTFTSDYSI2LDKK4QA1AFIEYLLEGG PSSGAPPP S3
(includes non-standard amino acids — Aib and MeL)
Molecular Formula: C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight: 4845.44 g/mol
CAS Number: 2.381089-83-2
PubChem SID: 474492335
Synonyms: Retatrutide, LY-3437943, NOP2Y096GV, triple agonist (GLP-1/GIP/glucagon)
Source: PubChem
Retatrutide has been evaluated in metabolic, endocrine, and molecular research settings. Published investigations highlight its ability to activate multiple receptor pathways involved in:
1. Glucose & Insulin Regulation
Research examines its effects on metabolic signaling networks associated with glucose handling and insulin sensitivity.[1]
2. Hormone Receptor Activity
Studies describe coordinated engagement of GLP-1, GIP, and glucagon receptors and downstream intracellular signaling events.[2]
3. Energy Balance & Weight Regulation
Laboratory research explores the peptide’s role in energy expenditure, nutrient partitioning, and systemic metabolic communication.[1]
4. Lipid & Cardiometabolic Pathways
Scientific interest includes its potential influence on lipid metabolism and hepatic signaling under controlled conditions.[2]
Retatrutide’s multi-agonist design allows researchers to investigate metabolic networks involving incretin biology, glucagon signaling, and endocrine system coordination. Its ability to activate several receptor systems simultaneously provides a unique platform for studying integrated metabolic physiology and hormone-driven cellular pathways.
Ongoing research continues to explore its structural, biochemical, and systemic properties within scientific and experimental environments.[1,2]
All products, descriptions, and scientific information provided on this website are intended solely for laboratory, scientific, and educational research. Retatrutide is not approved by the FDA and is not intended for human or veterinary use, consumption, injection, therapeutic application, or medical treatment. No content on this website should be interpreted as medical advice, guidance, or endorsement. Bodily introduction of any research compound is strictly prohibited.
Peptides are short chains of amino acids that occur naturally in organisms, where they act as messengers in many biological systems. While some peptides have been developed for medical use, laboratory research focuses on understanding their activity at the cellular level, examining how they impact essential processes in vitro.
Products from LabGrade Peptides are for in vitro research only. Please conduct your own research before working with these compounds. After purchasing, a team member will reach out via text for general support.
Orders are typically processed and shipped within 24 hours on weekdays. Delivery times vary by location, but most domestic orders arrive within 3–5 business days. You’ll receive tracking information as soon as your order ships.
Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.
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